Friday, 8 August 2014

And here I was thinking they were mythical creatures

Homozygous ApoE E4 centenarians. They exist. Without dementia.

Holy shit.

And he/she didn't have the "protective" mutation A673T, whatever that is. 

I know it doesn't make a lot of sense to get excited about this, hell we've all heard anecdotes of someone's uncle's step-mum living to 100 and smoking a pack a day for 85 years - but for those who know they have one or more Apolipoprotein E4 alleles, it may offer a glimmer of hope. 

The authors of the study (Yun Freudenberg-Hua et al) happened upon a 97 year old homozygous E4 carrier (E4/E4) with a MMSE (mini-mental state examination) score of 25.

Which in English means he/she had no clear signs of dementia at 97. 
"Disease variants in genomes of 44 centenarians" - Freudenberg-Hua et al
I'm guessing it was a woman, but they don't say. It sounds like the old duck had some other things going on that obviously affected her longevity and brain function in a positive way, but it's nice that the authors didn't just put it down to some freak case and continue to lay blame on the E4:



My gut feeling is that humans with E4 lived just as long as everyone else before it became customary to pour bucket loads of sugary shit down our throats. I have no proof of that, of course, but it makes logical sense to me.
Black Jewfish aren't mythical either. Which is good, because they taste delicious.