Friday, 8 August 2014

And here I was thinking they were mythical creatures

Homozygous ApoE E4 centenarians. They exist. Without dementia.

Holy shit.

And he/she didn't have the "protective" mutation A673T, whatever that is. 

I know it doesn't make a lot of sense to get excited about this, hell we've all heard anecdotes of someone's uncle's step-mum living to 100 and smoking a pack a day for 85 years - but for those who know they have one or more Apolipoprotein E4 alleles, it may offer a glimmer of hope. 

The authors of the study (Yun Freudenberg-Hua et al) happened upon a 97 year old homozygous E4 carrier (E4/E4) with a MMSE (mini-mental state examination) score of 25.

Which in English means he/she had no clear signs of dementia at 97. 
"Disease variants in genomes of 44 centenarians" - Freudenberg-Hua et al
I'm guessing it was a woman, but they don't say. It sounds like the old duck had some other things going on that obviously affected her longevity and brain function in a positive way, but it's nice that the authors didn't just put it down to some freak case and continue to lay blame on the E4:

My gut feeling is that humans with E4 lived just as long as everyone else before it became customary to pour bucket loads of sugary shit down our throats. I have no proof of that, of course, but it makes logical sense to me.
Black Jewfish aren't mythical either. Which is good, because they taste delicious.


  1. Pouring "sugary shit down our throats" is not to be recommended.

    Eating real food and not processed is something more and more are doing and feeling healthier for it. Perhaps we should tell more people about it?

    Keep spreading the real food gospel.

    All the best Jan

    PS Have a good weekend.

  2. Yeah, the collective voice seem to be getting louder. Unfortunately there will always be people who refuse to listen.

    Thanks, Jan.

    1. Alas .....that is so true. People do close their ears let alone their eyes and ignore the blindingly obvious.

      All the best Jan